Molecular Logic of DNMT3A1 Recruitment: Resolving Multivalency at the Chromatin Interface
Drew T. McDonald, Emma Sachs, Talia Rapoport, Daniel Niizawa, Manxin Cao, Nataly Konechne, Elizabeth Lee, Norbert O. Reich
This study investigates how DNMT3A1 binds nucleosomes through multivalent interactions and shows that avidity and commitment to catalysis govern its methylation specificity.
bioRxiv · Apr 29, 2026 · PreprintMolecular Biology