Clustered Mendelian Randomization analyses identifies distinct and opposing pathways in the causal association between insulin-like growth factor-1 and type 2 diabetes mellitus
Wenyi Wang, Ephrem Baraki Tesfay, Jan Bert van Klinken, Ko Willems van Dijk, Andrzej Bartke, Diana van Heemst, Raymond Noordam
This paper uses clustered Mendelian Randomization to identify distinct pathways linking IGF-1 to type 2 diabetes, showing opposing causal effects based on genetic instruments.
International Journal of Epidemiology · Jun 3, 2022Peer-reviewedGenetic & Genomic Medicine