Ko Willems van Dijk

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

Genome-wide Association Studies of Missing Metabolite Measures: Results From Two Population-based Studies

This study identifies genetic variants associated with missing metabolite measurements in two population-based cohorts, suggesting missingness is partly genetic and relevant for clinical and epidemiological research.

Sex- and Depression-specific Effects of Non-pathogenic CAG Repeats in HTT, ATXN3 and CACNA1A on Sleep

This study examines how non-pathogenic CAG repeats in HTT, ATXN3, and CACNA1A genes affect sleep outcomes, finding sex- and depression-specific associations.

Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors

This paper identifies age-specific genetic risk factors for cardiometabolic traits using genome-wide interaction analyses across multiple cohorts.

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

Clustered Mendelian Randomization analyses identifies distinct and opposing pathways in the causal association between insulin-like growth factor-1 and type 2 diabetes mellitus

This paper uses clustered Mendelian Randomization to identify distinct pathways linking IGF-1 to type 2 diabetes, showing opposing causal effects based on genetic instruments.

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

This GWAS identifies 123 migraine risk loci, including subtype-specific variants and novel targets, supporting neurovascular mechanisms in migraine.

Lifestyle Risk Score for aggregating multiple lifestyle factors: Handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

The paper evaluates methods to handle missing lifestyle data in gene-by-lifestyle interaction meta-analyses and recommends the Safe Approach for accuracy.

The genomic architecture of blood metabolites based on a decade of genome-wide analyses

This study estimates heritability and genetic contributions to metabolite levels using genome-wide data and twin-family cohorts, revealing class-specific genetic influences.

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate

This study examines how inbreeding affects type 2 diabetes-related metabolites in a Dutch genetic isolate, finding that inbreeding influences 32.9% of T2DM-related metabolites independently of BMI.

Recessive genetic effects on type 2 diabetes-related metabolites in a consanguineous population

The paper identifies recessive genetic variants associated with type 2 diabetes-related metabolites in a consanguineous population.