Delineating genotypes and phenotypes of individual cells from long-read single cell transcriptomes
Cheng-Kai Shiau, Lina Lu, Rachel E. Kieser, Kazutaka Fukumura, Timothy Pan, Hsiao‐Yun Lin, Jie Yang, Eric L. Tong, GaHyun Lee, Yuanqing Yan, Jason T. Huse, Ruli Gao
The paper introduces scNanoGPS, a toolkit for analyzing long-read single-cell transcriptomes to infer cell genotypes and phenotypes without short-read data, revealing cell-type-specific isoform and mutation patterns in tumors.
bioRxiv · Jan 24, 2023 · PreprintBioinformatics