Age-dependent ribosomal DNA variations and their effect on cellular function in mammalian cells
Eriko Watada, Sihan Li, Yutaro Hori, Katsunori Fujiki, Katsuhiko Shirahige, Toshifumi Inada, Takehiko Kobayashi
This study identifies age-dependent changes in rDNA copy number, methylation, and sequence variations in mice, linking these alterations to reduced pre-rRNA levels and shortened yeast lifespan.
bioRxiv · Jul 10, 2020 · PreprintGenetics