Takehiko Kobayashi

The paper reveals how Set2 deposits H3K36me3 on reassembled nucleosomes during transcription elongation using Cryo-EM structures of the EC-Set2-nucleosome complex.

The paper shows that Sir2 suppresses transcription near arrested replication forks in yeast rDNA to prevent copy number changes by directing DSB repair away from HR.

This study shows that Tsa1 stabilizes the rDNA cluster in budding yeast, preventing rDNA instability and extending lifespan.

This study shows that CAF-1 prevents Rad52-mediated rDNA instability during replication-coupled DNA repair in budding yeast by regulating replication fork arrest and resection.

This study identifies Spt4 as a factor that accelerates cellular senescence by promoting non-coding RNA transcription in rDNA clusters, leading to genomic instability and reduced lifespan in yeast.

The paper analyzes the structure and methylation of human rDNA using long-read sequencing, finding homogenization through gene conversion and a mechanism for maintaining active copies.

This study shows that Clb5 promotes rDNA stability by maintaining replication initiation efficiency, reducing recombination-dependent instability at replication fork barriers.

This study identifies age-dependent changes in rDNA copy number, methylation, and sequence variations in mice, linking these alterations to reduced pre-rRNA levels and shortened yeast lifespan.