NeuroscienceNeuropharmacologyPeer-reviewed
Amyloid-β promotes neurotoxicity by Cdk5-induced p53 stabilization
Rebeca Lapresa, Jesús Agulla, Irene Sánchez‐Morán…·Ángeles Almeida
This study shows that Aβ25-35 activates Cdk5, leading to p53 phosphorylation and stabilization, which causes neuronal damage and can be prevented by inhibiting Cdk5 or p53.
53 citations