Plasma cell identity escape drives resistance to anti-BCMA T-cell-redirecting therapy in multiple myeloma
Francesco Maura, Ciara Louise L. Freeman, Kylee H. Maclachlan, Marta Larráyoz, Bachisio Ziccheddu, Erin W. Meermeier, Juan‐José Garcés, Michael A. Durante, Holly Lee, Ross Firestone, Meghan A. Menges, Kayla M. Reid, Benjamin T. Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, , Kenneth H. Shain
The paper identifies genomic and transcriptional changes in multiple myeloma cells that drive resistance to anti-BCMA therapies, termed 'plasma cell identity escape'.
bioRxiv · Dec 11, 2025 · PreprintCancer Biology