Author

Ariosto Siqueira Silva

Moffitt Cancer CenterORCID 0000-0003-3237-9986Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Praneeth Reddy SudalaguntaiD· 3 shared Mark B. MeadsiD· 2 shared Anusuya M. RamasubramanianiD· 1 shared Bachisio ZicchedduiD· 1 shared Benjamin T. DiamondiD· 1 shared Ciara Louise L. FreemaniD· 1 shared Doris K. HanseniD· 1 shared Edward Lloyd BriercheckiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersEvolutionary Biology

Praneeth Reddy SudalaguntaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolutionary implications of phenotype switching for growth and survival of tumors in stochastic environments.

S. G. Babajanyan, Yuri I. Wolf, Rafael Renatino Canevarolo, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Eugene V. Koonin, Erez Persi

This study shows that tumor cells adapt to changing environments through phenotypic switching, with optimal survival achieved by blocking mesenchymal to epithelial transition.

bioRxiv · Aug 22, 2026 · PreprintEvolutionary Biology

Plasma cell identity escape drives resistance to anti-BCMA T-cell-redirecting therapy in multiple myeloma

Francesco Maura, Ciara Louise L. Freeman, Kylee H. Maclachlan, Marta Larráyoz, Bachisio Ziccheddu, Erin W. Meermeier, Juan‐José Garcés, Michael A. Durante, Holly Lee, Ross Firestone, Meghan A. Menges, Kayla M. Reid, Benjamin T. Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, , Kenneth H. Shain

The paper identifies genomic and transcriptional changes in multiple myeloma cells that drive resistance to anti-BCMA therapies, termed 'plasma cell identity escape'.

bioRxiv · Dec 11, 2025 · PreprintCancer Biology

An Advanced Framework for Time-lapse Microscopy Image Analysis

Qibing Jiang, Praneeth Reddy Sudalagunta, Mark B. Meads, Khandakar Tanvir Ahmed, Tara L. Rutkowski, Ken H. Shain, Ariosto Siqueira Silva, Wei Zhang

The paper introduces a computational pipeline for analyzing large-scale time-lapse microscopy data to predict cancer drug response in patient-specific contexts.

bioRxiv · Sep 21, 2020 · PreprintBioinformatics