Ferlin C2A-C2B linkers are alternatively spliced, intrinsically disordered, and interact with negatively charged membranes
Ethiene Kwok, Patricia A. Khuu, Patrick N. Reardon, Juan M. Vanegas, Colin P. Johnson
The paper identifies membrane-binding properties and alternative splicing effects in the C2A-C2B linker of vertebrate ferlins, showing its role in endocytosis and synaptic vesicle resupply.
bioRxiv · Mar 15, 2025 · PreprintMolecular Biology