Patrick N. Reardon

Ethanol consumption mediates parasitoid resistance via effects on host metabolism

The paper investigates how ethanol consumption affects host metabolism and parasitoid resistance in Drosophila larvae, finding that metabolic changes, not direct ethanol toxicity, mediate resistance.

Cooperative multivalency converts disorder into rods, resolving a paradox in cellular architecture

The paper shows how LC8 converts the disordered KANK1 linker into a rod-like structure through cooperative multivalency, resolving a cellular architecture paradox.

LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

This study shows that LC8 bridges 53BP1 trimers to enhance 53BP1 foci formation, which is critical for DNA repair.

Ferlin C2A-C2B linkers are alternatively spliced, intrinsically disordered, and interact with negatively charged membranes

The paper identifies membrane-binding properties and alternative splicing effects in the C2A-C2B linker of vertebrate ferlins, showing its role in endocytosis and synaptic vesicle resupply.

PermaPhosSer: autonomous synthesis of functional, permanently phosphorylated proteins

The paper develops a system to autonomously produce phosphorylated proteins in E. coli, demonstrating that non-hydrolyzable phosphoserine mimics phosphoserine function in three biological contexts.