Author
University Medical Center Groningen
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Arno van Hilten, Jeroen van Rooij, Bastiaan T. Heijmans…·Gennady V. Roshchupkin
The paper develops interpretable neural networks for multi-omics data to predict smoking status, age, and LDL levels, showing improved performance and generalizability across cohorts.
Paul J. Hop, René Luijk, Lucia Daxinger…·M. Arfan Ikram
The paper identifies 818 genes influencing DNA methylation in blood using genetic anchors and causal inference, revealing both transcription factors and non-DNA-binding proteins with regulatory roles.
René Luijk, Koen F. Dekkers, Maarten van Iterson…·Diana van Heemst
The paper identifies 49 gene drivers of downstream transcriptional changes using population genomics data and RNA-sequencing from 3,072 individuals.
Marc Jan Bonder, René Luijk, Daria Zhernakova…·C
The paper identifies trans-meQTLs linking disease variants to methylation changes at transcription factor binding sites, revealing eight-fold more downstream effects than trans-eQTLs.
Daria Zhernakova, Patrick Deelen, Martijn Vermaat…·Dorret
The paper identifies context-dependent eQTLs in peripheral blood RNA-seq data from Dutch individuals using a hypothesis-free approach, revealing gene expression influenced by cell type and signaling pathways.