Functionally constrained human proteins are less prone to disruption of stability caused by single amino acid substitutions
T. Daniel Andrews, Nicole Lehmann, Maryam May, Llewelyn Goodall, Eun Cho, Aaron Chuah
The paper quantifies how functionally constrained human proteins are less affected by stability-disrupting missense mutations and shows their depletion of extreme stability-changing variants in disease-free populations.
bioRxiv · Jul 14, 2024 · PreprintGenomics