Aaron Chuah

The paper quantifies how functionally constrained human proteins are less affected by stability-disrupting missense mutations and shows their depletion of extreme stability-changing variants in disease-free populations.

StabilitySort prioritizes pathogenic genetic variants by assessing their impact on protein stability using AlphaFold2 predictions.

The paper uses RNA-sequencing to study immune responses in retinal inflammation, identifying Factor B's role in macrophage infiltration and inflammation.