Human patient-specific FOXG1 syndrome mouse model revealed FOXG1-MYCN-mediated regulation of protein homeostasis in neurodevelopmental disorder
Shin Teo Jeon, Liwen Li, Jihwan Moon, Dongjun Shin, Jaein Park, Eunjin Kwak, Jae W Lee, Soo‐Kyung Lee
This study creates a patient-specific mouse model of FOXG1 syndrome and identifies disrupted protein homeostasis and neuroinflammation as key factors in the disorder's pathogenesis.
bioRxiv · Sep 27, 2025 · PreprintNeuroscience