Phosphorylation-dependent conformational change in the Keratin 19 head domain: Implications for filament assembly and binding to GSK3β and 14-3-3
Youngheum Ji, Minchan Jeong, Jewoo Kim, Jiwoo Yeom, Min Ae Han, Chaerim Park, Sang-Hoon Lee, Eunmi Hong, Young Ho Ko, Pierre A. Coulombe, Jin Hae Kim, Chang-Hun Lee
This study identifies a phosphorylation-dependent conformational change in the K19 head domain that affects filament assembly and interactions with GSK3β, but not 14-3-3 proteins.
bioRxiv · Nov 9, 2026 · PreprintBiochemistry