Mechanism of MEK1 activation by phosphorylation
Everett L. Jin, Levent Sari, Milo M. Lin
This study uses molecular dynamics simulations to show that double phosphorylation of MEK1 unwinds its helix, increases solvent exposure of catalytic residues, and induces correlated motion at the active site, enhancing enzymatic activity.
Biophysical Journal · Feb 26, 2026Peer-reviewedBiophysics