Levent Sari

This study uses molecular dynamics simulations to show that double phosphorylation of MEK1 unwinds its helix, increases solvent exposure of catalytic residues, and induces correlated motion at the active site, enhancing enzymatic activity.

This study maps how β-lactamase mutations confer resistance to different antibiotics, identifying generalist and specialist mutations with distinct mechanisms and positions.

The paper introduces a model to study how proteins transmit information over long distances without structural changes, finding that discrete motion enables this despite thermal noise.

This paper proposes a lever hypothesis for Synaptotagmin-1 action in neurotransmitter release, suggesting it pulls SNARE complexes to facilitate membrane fusion.

This study investigates how mutations in the C1C2B region of Munc13-1 affect neurotransmitter release and presynaptic plasticity in murine hippocampal cultures.

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.