Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature
K. Moreau, M.-A. Trapotsi, E. Mouchet, G. Williams, T. Monteverde, K. Juhani, R. Turkki, F. Miljkovic, A. Martinsson, L. Mervin, E. Mullers, I. Barrett, O. Engkvist, A. Bender
This study uses cell morphological profiling to identify phenotypic signatures of PROTACs, revealing mitotoxicity that cannot be predicted from individual components.
bioRxiv · Jan 17, 2022Pharmacology & Toxicology