Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant.
T. Singh, S. Kalamajski, J. P. M. C. M. Cunha, S. Hladkou, F. Roberts, S. Gheibi, A. Soltanian, K. Yektay Farahmand, O. Ekstrom, A. Mamidi, P. W. Franks, A. Rosengren, H. Semb, H. Mulder, M. Fex
This study uses hiPSC and hESC to model the MTNR1B risk variant's effect on β-cell function, finding increased MTNR1B protein and melatonin sensitivity in G-allele carriers.
bioRxiv · Jul 19, 2024 · PreprintCell Biology