Physical mechanisms of red blood cell splenic filtration
A. Moreau, F. Yaya, H. Lu, A. Surendranath, A. Charrier, B. Dehapiot, E. Helfer, A. Viallat, Z. Peng
This paper investigates how red blood cells pass through narrow splenic slits using multiscale modeling, live imaging, and microfluidic experiments, finding that cells deform into two tether-connected spheres and unfold their cytoskeleton to pass through.
bioRxiv · Jan 10, 2023Biophysics