Procedure-Matched Comparison of TNBS/Ethanol Enema and DSS Free-Drinking Models of Ulcerative Colitis in Rats: Immune Endotype Profiling and a Translational Model-Selection Framework
Yongkang AN, Fang wufang, L Zhang, Menghua Shi, Shuangxi Zhang, Xiangan Zhang
This paper compares TNBS/ethanol enema and DSS free-drinking models of UC in rats, showing TNBS induces higher Th1-polarized inflammation and DSS reflects innate barrier disruption, with recommendations for model selection based on therapeutic targets.
bioRxiv · Jun 8, 2026 · PreprintAnimal Behavior & Cognition