Low-pass Whole Genome Imputation Enables the Characterization of Polygenic Breast Cancer Risk in the Indigenous Arab Population
Mohammed A. Aljumaan, Hoyin Chu, Abdullah Al-Sulaiman, Sabrina Yvonne Camp, Seunghun Han, Riaz Gillani, Yousef Al Marzooq, Fatmah Almulhim, Chittibabu Vatte, Areej Manssour Al Nemer, Afnan Almuhanna, Eliezer M. Van Allen, Amein K. Al‐Ali, Saud H. AlDubayan
This study uses low-pass whole genome sequencing to impute variants and construct polygenic risk scores for breast cancer in an underrepresented Arab population, finding associations with family history and age of presentation.
medRxiv · Dec 7, 2022 · PreprintGenetic & Genomic Medicine