Seunghun Han

Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancers

The paper identifies polygenic risk factors and rare variants in unexplained familial cancers using whole genome sequencing and family history data.

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA

The paper engineers TALE-linked deaminases to reduce off-target edits in mtDNA editing, resulting in mice with Leigh disease mutations and reduced heart rates.

Low-pass Whole Genome Imputation Enables the Characterization of Polygenic Breast Cancer Risk in the Indigenous Arab Population

This study uses low-pass whole genome sequencing to impute variants and construct polygenic risk scores for breast cancer in an underrepresented Arab population, finding associations with family history and age of presentation.

Mutational footprint of platinum chemotherapy in a secondary thyroid cancer

This paper reports a case where platinum chemotherapy exposure was linked to the development of aggressive thyroid cancer through mutational signatures and genomic analysis.

Germline predisposition to pediatric Ewing sarcoma is uniquely characterized by inherited pathogenic variants in DNA damage repair genes

This study identifies inherited pathogenic variants in DNA damage repair genes as a distinct germline risk factor for Ewing sarcoma, with FANCC showing significant enrichment.