Beyond Natural Antibodies: Scaffold-Based Generation of Novel Anti-3CLpro Nanobody Nb01
Zhijie Zhan, Jun Xiong, Yini Jiang, Yinghua Li, Yuanzhe Cai, Chong T. Luo, Feijuang Huang, Jieren Liu
This paper develops a nanobody Nb01 targeting SARS-CoV-2 3CLpro, showing broad-spectrum neutralizing activity against multiple variants with higher affinity than existing nanobodies.
bioRxiv · May 6, 2025 · PreprintBioinformatics