Accelerating scRNA-seq analysis: automated cell type annotation using representation learning and vector search
Stephen R. Williams, Fedor Grab, Govinda M. Kamath, Yerdos A. Ordabayev, Jeff Mellen, Patrick Roelli, Kristian Cibulskis, Erik M Lehnert, Fen Xie, Miguel Covarrubias, Nur-Taz Rahman, Timothy L. Tickle, Emre Erhan, Nicolas Malfroy-Camine, Kevin Lydon, , Nigel F. Delaney
This paper introduces a service for automated cell type annotation in scRNA-seq data using reverse search against a curated database, providing both fine-grained and coarse annotations without relying on predefined markers.
bioRxiv · Oct 6, 2025 · PreprintBioinformatics