Double Machine Learning with Multi-Gene Shared Backgroundfor Causal Inference in Single-Cell Data: Grouping Deviation Follows a Random Walk and the Accuracy-Compute Trade-Off
Wei Ye, Xinyu Jiang, Feng(Ben) Shen
The paper introduces a Randomized Partition Strategy for efficient double machine learning in single-cell data, showing accuracy loss follows a random walk and compute savings are predictable.
bioRxiv · Aug 10, 2026 · PreprintSystems Biology