Wei Ye

Microglia stabilize sleep homeostasis via adenosine A3 receptor signaling

This study shows microglia regulate sleep homeostasis through adenosine A3 receptor signaling, stabilizing wakefulness and NREM sleep by modulating calcium activity in response to brain state changes.

Double Machine Learning with Multi-Gene Shared Backgroundfor Causal Inference in Single-Cell Data: Grouping Deviation Follows a Random Walk and the Accuracy-Compute Trade-Off

The paper introduces a Randomized Partition Strategy for efficient double machine learning in single-cell data, showing accuracy loss follows a random walk and compute savings are predictable.

Comparison of nuisance function construction strategies for double machine learning causal inference in single-cell transcriptomics: shared unsupervised deep learning does not require cross-fitting

The paper compares three nuisance function construction strategies for causal inference in single-cell transcriptomics, finding that shared unsupervised deep learning performs well without cross-fitting.

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular Carcinoma

This study develops a niclosamide prodrug (NIC-PS) with improved bioavailability and shows it targets VASN-TGFβ signaling to reduce HCC tumor volume and enhance therapeutic responses.