Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment
Lingjie Li, Yong Wang, Jessica L. Torkelson, Gautam Shankar, Jillian M. Pattison, Hanson H. Zhen, Zhana Duren, Fengqin Fang, Sandra P. Melo, Samantha N. Piekos, Jiang Li, Eric J. Liaw, Lang Chen, Rui Li, Marius Wernig, , Anthony E. Oro
The paper identifies TFAP2C and p63 as key regulators of epidermal lineage commitment and shows TFAP2C initiates differentiation while p63 drives maturation through chromatin dynamics.
bioRxiv · Jun 18, 2018 · PreprintCell Biology