Anthony E. Oro

The paper identifies a novel cancer susceptibility mutation in hfBCC patients by analyzing skin mutagenesis and its association with BCC and prostate cancer.

The paper develops a spatiotemporal multi-omics platform and machine-learning tool to manufacture hPSC-derived esophageal mucosa.

The paper integrates single-cell chromatin and transcriptomic data from human scalp to identify gene regulatory mechanisms and causal variants in hair and skin diseases.

This study identifies MTSS1/Src family kinase dysregulation as a common mechanism in multiple inherited ataxias and shows SFK inhibitors can delay disease progression in mouse models.

The paper identifies TFAP2C and p63 as key regulators of epidermal lineage commitment and shows TFAP2C initiates differentiation while p63 drives maturation through chromatin dynamics.

The paper investigates how morphogens and p63 interact to regulate chromatin dynamics during keratinocyte differentiation from hESCs, revealing p63's dependence on morphogenetic signaling for long-range chromatin interactions.