Major surgery induces acute changes in DNA methylation associated with activation of the immune response.
Ryoichi Sadahiro, Bridget Knight, Ffion James, Eilis J. Hannon, John A.F. Charity, Ian R. Daniels, Joe Burrage, Olivia Knox, Bethany Crawford, Neil James Smart, Jonathan S. Mill
This study shows major surgery causes acute DNA methylation changes in immune-related genes, linked to inflammation markers like CRP and IL-6, persisting until hospital discharge.
Scientific Reports · Apr 1, 2020Peer-reviewedGenomics