Bridget Knight

Genetic scores explain variation in birthweight that is not captured by easily measured clinical and anthropometric variables

This paper shows genetic scores explain additional variance in birthweight beyond clinical variables, with maternal and fetal genetic scores adding 6.0% variance when combined.

Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

This study examines genetic scores for birth weight in South Asians, finding associations with birth size, childhood body size, and adult cardiometabolic markers.

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

The paper examines the effect of fetal genetic predispositions to metabolically favourable adult adiposity and BMI on birth weight and other anthropometric traits, finding stronger associations with birth weight for the adiposity alleles.

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

This study uses Mendelian Randomisation to show that maternal metabolically favourable adiposity is associated with lower offspring birth weight compared to general adiposity indexed by BMI.

Common maternal and fetal genetic variants show expected polygenic effects on the probability of being born small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies

Major surgery induces acute changes in DNA methylation associated with activation of the immune response.

This study shows major surgery causes acute DNA methylation changes in immune-related genes, linked to inflammation markers like CRP and IL-6, persisting until hospital discharge.

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

The paper shows androgen-regulated ESRP2 transcription controls alternative splicing in prostate cancer, with implications for metastasis.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.