Breaking the link between demyelination and axon loss: SARM1 inhibition as a neuroprotective strategy for multiple sclerosis
Micah Feri, Stephanie R. Peterson, Melika Rezanejad, Flavio Cardenas, Alyssa Anderson, Brandon Poole, Moyinoluwa T. Ajayi, Sung Hoon Kim, John A. Katzenellenbogen, Seema Kaushalya Tiwari-Woodruff
This study shows that inhibiting SARM1 protects axons and improves function in MS models without affecting demyelination or inflammation.
bioRxiv · Sep 27, 2026 · PreprintNeuroscience