Exogenous fatty acids inhibit fatty acid synthesis through competition between endogenously- and exogenously-generated substrates for phospholipid synthesis in Escherichia coli
Stefan Pieter Hendrik van den Berg, Adja Damba Zoumaro-Djayoon, Flora Yang, Gregory Bokinsky
The paper shows exogenous fatty acids inhibit fatty acid synthesis in E. coli by competing with endogenous substrates for phospholipid synthesis enzymes, leading to accumulation of long-chain acyl-ACP and altered membrane lipid balance.
FEBS Letters · Dec 30, 2024Peer-reviewedMolecular Biology