Francesca Luca

Efficient Integrative Multi-SNP Association Analysis using Deterministic Approximation of Posteriors

This paper introduces DAP, a method for efficient integrative multi-SNP association analysis that improves computational efficiency and rigor in incorporating genomic annotations into GWAS and molecular QTL mapping.

A high-throughput RNA-seq approach to profile transcriptional responses

The paper introduces a two-step RNA-seq approach to efficiently profile transcriptional responses to multiple treatments across cell lines.

Cross-population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation

This study improves eQTL discovery and fine mapping by analyzing data across multiple populations, finding that variants disrupting transcription factor binding are enriched in eQTLs.

Which genetic variants in DNase I sensitive regions are functional?

The paper identifies functional genetic variants in DNase I sensitive regions by integrating sequence and footprinting data, finding they are enriched for allele-specific binding and GWAS traits.

QuASAR: Quantitative Allele Specific Analysis of Reads

QuASAR jointly infers genotypes and allele-specific expression while accounting for sequencing errors and allelic over-dispersion, showing effectiveness when genotypes are unavailable.