Yeji Lee

This study shows that modifying ionizable lipids and formulation parameters of mRNA vaccines can enhance CD4+ T cell immunity and improve vaccine efficacy.

This paper introduces a dual-function ionizable lipid that reduces mRNA toxicity and enhances clearance, achieving high gene editing efficiency in a macular degeneration model.

DAP-G adds false discovery rate control and credible sets to Bayesian multi-SNP association analysis, runs about 20 times faster than existing software, and defines summary statistics matching individual-level data.

This paper introduces DAP, a method for efficient integrative multi-SNP association analysis that improves computational efficiency and rigor in incorporating genomic annotations into GWAS and molecular QTL mapping.