Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma
Rama Kadamb, Melisa Lopez Anton, Timothy J. Purwin, Lornella Seeneevassen, Vivian Y.L. Chua, Francis Waltrich, Jessica L.F. Teh, Maria Angela Nieto, Takami Sato, Mizue Terai, Sergio Roman‐Roman, Leanne de Koning, Deyou Zheng, Andrew E. Aplin, Julio A. Aguirre‐Ghiso
This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.
bioRxiv · Mar 5, 2024 · PreprintCancer Biology