Julio A. Aguirre‐Ghiso

Matrix biophysical cues drive transient or prolonged breast cancer dormancy programmes

This study shows that matrix stiffness influences breast cancer cell dormancy states, with soft matrices inducing transient dormancy and stiff matrices causing prolonged dormancy.

A Developmental Lectin-Glycan Program Enables Early Breast Cancer Dissemination and Metastatic Onset

This study identifies a developmental GAL1-glycan program that promotes early breast cancer dissemination and metastasis by reactivating mammary stem cell traits and epithelial plasticity.

Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis

This study shows that ZFP281 expression delays breast cancer initiation and prevents metastasis by enforcing a dormant state in cancer cells.

Quiescent OXPHOS-high triple-negative breast cancer cells that persist after chemotherapy depend on BCL-XL for survival

This study identifies OXPHOS-high quiescent triple-negative breast cancer cells that survive chemotherapy and depend on BCL-XL for survival, showing that targeting BCL-XL enhances chemotherapy efficacy.

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma

This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.