Dysregulated mechanoregulation of load-induced bone adaptation in prematurely aged mice: insights from a micro-multiphysics agent-based model
Daniele Boaretti, Francisco C. Marques, Gisela Anna Kuhn, Amit Singh, Friederike A. Schulte, Ralph Müller
This study uses an agent-based model to show that aging disrupts mechanoregulation of bone adaptation in mice, leading to altered bone formation and resorption dynamics.
bioRxiv · Oct 23, 2026 · PreprintSynthetic Biology