Ralph Müller

This study uses an agent-based model to show that aging disrupts mechanoregulation of bone adaptation in mice, leading to altered bone formation and resorption dynamics.

The paper examines how mechanical loading and pharmacological therapies affect osteocyte lacunar morphology in a mouse osteoporosis model, showing distinct adaptations in lacunar density, volume, and sphericity.

This study investigates how cell-scale micropores in synthetic hydrogels affect osteocyte-like morphogenesis and osteogenic differentiation in vitro.

This study shows that combining physical and pharmacological anabolic therapies improves bone strength and mechanoregulation in female mice with osteoporosis.

This study combines volumetric bioprinting with mineralization to create high-density cell-laden hydrogel constructs with bone-like properties.

This study shows that aged bone retains mechanosensitivity, with mechanical loading improving regeneration in a mouse model of premature aging.

Spatial μProBe integrates multimodal imaging to analyze spatial gene expression and mechanical environments in musculoskeletal tissues.

The paper develops a 3D bioprinted bone model from patient-derived cells to study donor-specific therapeutic responses to DKK1Ab in osteogenesis imperfecta.

This study uses spatial transcriptomics to analyze gene expression in relation to mechanical strain in fracture healing, identifying strain-dependent gene expression patterns.

This study characterizes frailty in PolgA mice, showing sex-specific differences and parallels to human aging.

This study examines daily metabolic and locomotor rhythms in prematurely ageing PolgA mice, finding sex-specific differences in activity and metabolic patterns.

The paper uses 3D-bioprinted bone models to show dysregulated mineralization in FKBP10-related osteogenesis imperfecta compared to healthy controls.

This study uses real-time finite element analysis to individualize mechanical loading in a mouse fracture healing model, reducing strain variance and improving healing outcomes.

This study characterizes the local and global geometry of human trabecular bone using curvature maps and Minkowski functionals, revealing complex curvature patterns and new insights into anisotropy.

The paper describes a micro-CT mouse holder for femur defect experiments, providing heating and anaesthetic gas for accurate scanning.

The paper reports intracranial calcification in P301L mice associated with tau pathology and bone protein deposits, using MRI and micro-CT imaging.

The paper evaluates if upscaling in vivo HR-pQCT images improves the accuracy of microstructural bone adaptation simulations using ex vivo validation.