Author

Frans B.L. Hogervorst

The Netherlands Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Anna González‐NeiraiD· 2 shared Anna JakubowskaiD· 2 shared D. Gareth EvansiD· 2 shared Gord GlendoniD· 2 shared Irene Louise AndrulisiD· 2 shared Joe DennisiD· 2 shared kConFab Investigators· 2 shared Manjeet K. BollaiD· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Anna González‐NeiraORCID

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3 papers

Recent·Most cited

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

Daniel R. Barnes, Jonathan P. Tyrer, Joe Dennis, Goska Leslie, Manjeet K. Bolla, Michael J. Lush, Amber M. Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene Louise Andrulis, Hoda Anton‐Culver, Aðalgeir Arason, Banu Arun, Judith Balmañà, Elisa Victoria Bandera, , Kirsten B. Moysich

This study identifies seven novel genetic loci associated with high-grade serous ovarian cancer risk using a large-scale GWAS and develops polygenic scores for improved risk prediction.

medRxiv · Feb 29, 2024 · PreprintGenetic & Genomic Medicine

Impact of genetic counselling strategy on diagnostic yield and workload for genome sequencing-based tumour diagnostics

Roelof Koster, Luuk J. Schipper, Noor A. A. Giesbertz, Daphne M. van Beek, Matías Mendeville, Kris G. Samsom, Efraim H. Rosenberg, Frans B.L. Hogervorst, Paul Roepman, Mirjam C. Boelens, Linda J.W. Bosch, José G. van den Berg, Gerrit A. Meijer, Emile E. Voest, Edwin P. J. G. Cuppen, , Kim Monkhorst

This study evaluates genetic counselling strategies for genome sequencing-based tumour diagnostics, finding that post-test strategies reduce unnecessary referrals while maintaining PGV detection rates.

Genetics in Medicine · Nov 22, 2023Peer-reviewedGenetic & Genomic Medicine

Breast cancer risks associated with missense variants in breast cancer susceptibility genes

Leila Dorling, Sara Carvalho, Jamie Allen, Michael T. Parsons, Cristina Fortuño, Anna González‐Neira, Stephan Heijl, Muriel A. Adank, Thomas U. Ahearn, Irene L. Andrulis, Päivi Auvinen, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, , Javier J. Benitez

The paper assesses breast cancer risks linked to rare missense variants in five susceptibility genes using logistic and mixture models, finding varying risk contributions across genes.

Genome Medicine · May 18, 2022Peer-reviewedGenetic & Genomic Medicine