Paul Roepman

This study compares whole-genome sequences of adolescent and young adult solid cancers to older adult cancers, finding shared genetic drivers but age-related differences in mutational processes and germline variants.

The paper develops a statistical framework to identify genomic non-response biomarkers in cancer therapies using whole-genome and transcriptome sequencing data from 2,596 patients.

This study evaluates genetic counselling strategies for genome sequencing-based tumour diagnostics, finding that post-test strategies reduce unnecessary referrals while maintaining PGV detection rates.

This study validates whole genome sequencing as a reliable single assay for detecting various cancer mutations with high sensitivity and precision.

VIRUSBreakend identifies viral DNA integration with high sensitivity and low false discovery rate using single breakend variant calling in cancer genomes.