Author

Fred R. Hirsch

Mount Sinai Health SystemPrimary ORCID profile (0000-0002-6885-1894 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Fred R. HirschiD2 papers · Tisch Cancer Institute

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Chris J. RivardiD· 1 shared G. E. Brooks· 1 shared Iñigo San-MillániD· 1 shared Janel L. Martinez· 1 shared Shivaun Lueke Pickard· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

Chris J. RivardORCID

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1 paper

Recent·Most cited

Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell Lines

Iñigo San-Millán, Janel L. Martinez, Shivaun Lueke Pickard, Fred R. Hirsch, Chris J. Rivard, G. E. Brooks

This study shows that chronic lactate exposure in cancer cell lines induces lineage-specific immune checkpoint gene expression patterns, suggesting lactate drives broader immune escape mechanisms beyond single-checkpoint regulation.

bioRxiv · Jan 12, 2026 · PreprintCancer Biology