Iñigo San-Millán

Decreased Mitochondrial Bioenergetics and Function Define a Distinct Metabolic Phenotype in Healthy Sedentary Individuals Detectable Through Non-Invasive CPET

This study identifies a distinct mitochondrial metabolic phenotype in sedentary individuals using non-invasive CPET and finds reduced mitochondrial function and bioenergetics compared to active individuals.

Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell Lines

This study shows that chronic lactate exposure in cancer cell lines induces lineage-specific immune checkpoint gene expression patterns, suggesting lactate drives broader immune escape mechanisms beyond single-checkpoint regulation.

Metabolic Responses of Different Levels of Fitness

This study examines metabolic and physiological responses to exercise across four fitness levels in male cyclists, finding hierarchical patterns in performance and metabolic parameters.