How ATP and dATP act as molecular switches to regulate enzymatic activity in the prototypic bacterial class Ia ribonucleotide reductase
M. A. Funk, C. M. Zimanyi, G. A. Andree, A. E. Hamilos, C. L. Drennan
This study investigates how ATP and dATP regulate E. coli class Ia ribonucleotide reductase activity through structural analysis of six crystal forms, revealing conformational changes and a novel ATP binding site.
bioRxiv · Jul 31, 2021 · PreprintBiochemistry