Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.
R. R. Cupo, A. Rizo, G. A. Braun, E. Tse, E. Chuang, D. R. Southworth, J. Shorter
The paper reports the structure of Skd3-substrate complex, revealing its dodecamer formation and mechanism of protein disaggregation, with implications for SCN and MGCA7.
bioRxiv · Feb 17, 2022Biochemistry