A Practical Assay for Assessing Mean Red Blood Cell Age Using the Protein 4.1a/4.1b Ratio
E. Seiler, N. Bender, P. Eppenberger, C. Hobbs-Ray, G. Baerlocher, Asya Makhro
This paper develops a low-volume method to measure the 4.1a/4.1b protein ratio in red blood cells to estimate mean RBC age, showing significant interindividual variation.
bioRxiv · Oct 9, 2026 · PreprintBiochemistry