Integrating Semantic Retrieval, LLM-based Refinement, and Structured Expert Curation for Scalable AOP Gene Mapping
Alexandra Schaffert, Michele Fratello, Kaisla Kangas, Marcella Torres Maia, Giusy del Giudice, Lena Möbus, Cristina Accardi, Zeyad Al-Abdulraheem, Lorenzo Campini, Francesco Galardo, Antonio Federico, G. Ciancaleoni, Hanna‐Kaarina Juppi, Martin Paparella, Angela Serra, Dario Greco
The paper presents an AI workflow for mapping Key Events to genes in Adverse Outcome Pathways, improving accuracy and reducing manual effort through semantic retrieval, LLM refinement, and expert curation.
bioRxiv · Jun 30, 2026 · PreprintBioinformatics