Alexandra Schaffert

A Data-Driven Approach for the Development of a Time-informed Adverse Outcome Pathway-network for Cardiotoxicity of Environmental Chemicals

This paper develops a time-informed Adverse Outcome Pathway (AOP) network for environmental chemical-induced cardiotoxicity using data-driven methods and identifies key processes linking perturbations to cardiac injury.

Integrating Semantic Retrieval, LLM-based Refinement, and Structured Expert Curation for Scalable AOP Gene Mapping

The paper presents an AI workflow for mapping Key Events to genes in Adverse Outcome Pathways, improving accuracy and reducing manual effort through semantic retrieval, LLM refinement, and expert curation.