Witnessing the Structural Evolution of an RNA Enzyme
X. Portillo, Y.-T. Huang, R. R. Breaker, D. P. Horning, G. F. Joyce
The paper tracks the structural evolution of an RNA polymerase ribozyme, showing it develops a new tertiary structure near the active site, enhancing catalytic activity through multiple evolutionary paths.
bioRxiv · Jun 22, 2021Biochemistry